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Orphaned Matilda is not at all pleased when she arrives at Blood and Bone Alley to become an assistant to Red Peg the Bonesetter. She is a religious, well-educated girl who can't picture herself doing dirty chores or helping sickly patients.

In the summer of 1849, Lucy Whipple's mother packs up her household and her two young children, and leaves their home in Massachusetts for the gold fields of California.

In 1881, 12-year-old Rodzina Clara Jadwiga Anastazya Brodski wishes she didn't have to board the orphan train in Chicago. But she has no home, no family, and no choice. Rodzina doesn't believe the orphans are on their way out West to be adopted by good families. She's sure they will become slaves to strangers. Anyway, who would ever adopt a large, tough, stubborn girl of Polish origin?

Francine lives down the street from a Hollywood film studio, adores screen dreamboat Montgomery Clift, and sometimes sees her home life as a scene from a movie: Dinner at the Greens. She wishes she really were a movie star, brave and glamorous and always ready to say the right thing.